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Description

NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

IGF-1 is responsible for most of growth hormones fat-burning and muscle-preserving effects

doi: 10.1007/978-3-642-11416-8 56 DanielJ.MaamarH.DebC.SirakovaT

6,7,8,38,39 In contrast to oncogenic mutations, which often occur at specific loci and result in hyperactivation of the gene product, inactivating mutations observed in tumour suppressor genes such as NF1 are not site specific